A Guide to AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
Actually, ATP is the most significant energy molecule in the body. In essence, this is the starting point of cellular function. Because energy is being used by cells, ATP is breaking down into ADP which has less potential for energy. ADP is broken down to AMP containing the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
There are different mechanisms in which AMPK acts on. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – as we begin to age, AMPK activation begins to decline. Some experts think that AMPK is among the contributing factors for aging. It is promoting cellular renewal and also, the production of new mitochondria.
Anti inflammation – it is interesting to know that AMPK activation helps in decreasing inflammation but this too can be decreased by inflammation.
Anti diabetic – you may find it odd but AMPK is now more and more understood especially when it comes to its part of treating diabetes with its capacity to improve insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. This has been uncovered to have anti obesity effect and can increase insulin sensitivity.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – not just that it is an AMPK activator, it has berberine containing metformin which is great for anti-diabetes.